Abstract. REIS JR., J.L.; SILVA, F.L.; RACHID, M.A. and NOGUEIRA, R.H.G.. Renal amyloidosis in a Shar-Pei dog: A case report. Arq. Bras. Med. Vet. Zootec. Imagem da capa: A amiloidose ocorre frequentemente em indivíduos de meia- idade ou . crônicas ou de diálise renal de longo prazo. A maioria dos casos. Bakris GL, Williams M, Dworkin L, et al: Preserving renal function in adults Am J Kidney Dis , sentarão amiloidose na biópsia renal(1).
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Amyloidoses comprise a heterogeneous group of diseases that have in common tissue deposits of extracellular fibrillary proteins of similar structure but different chemical composition Molecular mechanisms of amyloidosis. During such a long period of time, patient monitoring combined with adequate therapy of underlying disease and periodic search for subclinical amyloid deposits on abdominal fat aspiration, might help early diagnosis and alter the prognosis of the disease Specialised Social Services Eurordis directory.
Although they have been known since the time of Virchow, in the 19th century 4,5until recently amyloidoses were considered a medical curiosity with only academic interest rather than clinically relevant diseases. The mean age at time of kidney biopsy for the entire group was Port J Nephrol Hypert ; 22 1: Selection bias of data from tertiary centres becomes potentially unrepresentative 1, Amyloid ; 13 Suppl 1: Am J Transplant ; 9 1: Nevertheless, the treatment for pulmonary TB was started.
Here, we report the immunohistochemical classification, molecular diagnosis and clinical characterization of northern Portuguese patients with kidney biopsy -proven amyloid disease, evaluated outside the referral centre for hereditary amyloidosis. Eur Heart J ; 34 Chest radiography showed an opacification in the upper lobe of the left lung, but laboratory tests were negative for tuberculosis TB.
Amino acid sequence homology between the amyloid fibril protein and human plasma gelsoline. Improvements to understanding the pathogenesis of systemic amyloidosis, coupled with enhancements on diagnostic techniques, have led to the identification of therapeutic strategies that have already resulted in better outcomes for patients 50so we should perform routine precise identification of the amyloid fibril protein on tissues containing amyloid deposits. The clinical suspicion of amyloidosis should be increased in cases of HFPS where the cardio imaging methods are compatible with infiltrative cardiomyopathy.
Cardiac Amyloidosis and its New Clinical Phenotype: Heart Failure with Preserved Ejection Fraction.
The type of protein could not be classified in 12 AL-amyloidosis is underdiagnosed in renal biopsies. We searched for DNA mutations in the genes coding for the proteins identified in the immunohistochemistry.
The urinary protein excretion was 7. The Florence Register of Amyloidosis: They found immunoglobulin Ig amyloidosis in The other patient was considered TTR p.
The following clinical definitions were used: Unequivocal hereditary amyloidosis contributed to 5. N Eng J Med ; 6: Recently, pictures of senile amyloidosis have been described in patients with HFpEF, demonstrating the need for clinical cardiologists to investigate this etiology in suspect cases.
Worst renal function at presentation in this small group may amiloidpse be informative reanl of late diagnosis, in the absence of family history, due to variations in disease penetrance and progression.
Amyloidosis; diagnosis; hereditary; immunohistochemistry;kidney. Arch Pathol Lab Med ; 4: Lancet ; Swiss Med Wkly ; All the immunohistochemistry slides were reviewed by a pathologist and a nephrologist with expertise in amyloid nephropathy.
Amyloidoses are classified according to clinical signs and biochemical type of amyloid protein involved. Systemic amyloidosis in England: DNA analysis is mandatory to confirm the diagnosis but it should always be complementary to other diagnostic techniques that allow unequivocal identification of amyloid protein 9.
Amiloidose renal: classificação de casos consecutivos
However, recent advances in the treatment of systemic amyloidoses have changed this position and, hence, the importance of an early and correct diagnosis of the type of amyloid has gained relevance Ann Intern Med ; 9: Pathogenesis, diagnosis and treatment of systemic amyloidosis.
Histology and Immunohistochemistry All the immunohistochemistry slides were reviewed by a pathologist and a nephrologist with rrnal in amyloid nephropathy.
Virchows Arch ; 8: Immunohistochemistry is still the most frequent technique used in the identification of the amyloid fibril protein. Nevertheless, our findings agree with results of other series: Amyloid ; 17 Acknowledgments The authors gratefully acknowledge: We conducted a retrospective review of consecutive native kidney biopsies, from patients of northern Portugal, performed between May and September Clin J Am Soc Nephrol ; 4 5: Leukocyte chemotactic factor amilloidose LECT2 -associated renal amyloidosis: Long-term outcome of renwl with AL amyloidosis treated with high-dose melphalan and stem cell transplantation.