However, the role and relationship of activated macrophages with g. Key Words: Gastric cancerMacrophageInflammationNuclear . with gastric cancer, 20 patients with gastric benign lesions and 30 healthy Prasad S, Ravindran J, Aggarwal BB: Nf-kappab and cancer: How intimate is this relationship. The vast majority of studies on NF-κB in cancer have focused on p65 BB ( ) NF-kappaB and cancer: how intimate is this relationship. A direct role of the NF-κB pathway in arsenic-induced apoptosis is shown by of xenotransplanted LCy Hodgkin tumors concomitant with NF-κB inhibition. .. To show a causal relationship between inhibition of NF-κB and arsenic-induced .. Van Antwerp D, Miyamoto S. Rel/NF-kappa B/I kappa B family: intimate tales.
Moreover, in an extend view on the SASP program as a senescence-associated pro-inflammatory signaling array, this phenotype is not restricted to secreted factors, but also includes membrane-bound cell surface molecules serving as ligands and receptors, for instance TNF receptors, CXCR2 or the IL-6R, thereby creating potential autocrine loops e.
IL-6 and the IL-6Rand self-amplifying cascades e. Therefore, the expression of surface-presented receptors and ligands and the secretion of a plethora of factors by senescent cancer cells may have complex, growth-inhibitory or -promoting effects on adjacent tumor and surrounding bystander cells.
In particular, factors secreted by senescent cells can also act on macrophages, neutrophils, and NK cells, thereby promoting immune responses that, on one hand, may ultimately lead to the clearance of senescent tumor cells Xue et al. Given our own observation that macrophage-derived TGFb evokes lymphoma cell senescence in a non-cell-autonomous fashion Reimann et al. Thus, the outcome of anticancer therapy is not only determined by a quantitative effect on cancer cells forced to irreversibly exit the cell cycle but may also depend on novel capabilities acquired by senescent cells that can impact on their malignant and non-malignant neighbors in different ways.
With further elucidation of these complex interdependencies that regulate tumor cell survival, senescence, and immune clearance, we expect non-genotoxic senescence-inducing agents to become a very promising perspective to be further exploited in cancer treatment.
The possible outcomes of chemotherapeutic treatments reach from necrosis, apoptosis, mitotic catastrophe, and autophagy to cellular senescence. Most of the chemotherapeutic agents used in the clinic are assumed to exert their anti-tumor effect through the induction of apoptosis.
Accordingly, cancer cells with apoptotic defects would exhibit chemoresistance. However, such treatment should be applied with caution. Only canonical classical pathway is shown.
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Extracellular stimuli transmitted though receptor complexes activate IKK via phosphorylation. A model of how oncogenic network influences cancer treatment outcome. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. The two NF-kappaB activation pathways and their role in innate and adaptive immunity.Cancer Prevention Through Immunomodulation: Does Diet Play a Role?
Oncogene-induced senescence as an initial barrier in lymphoma development. Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer.
NF-κB and cancer: how intimate is this relationship
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
The senescence-associated secretory phenotype: Constitutive nuclear factor kappa B activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.
Immunity, inflammation, and cancer.
Molecules and Cells
Shared principles in NF-kappaB signaling. The t 14;18 defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma.
The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus. Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB. Myc suppression of Nfkb2 accelerates lymphomagenesis.
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Abstract Quercetin can inhibit the growth of cancer cells with the ability to act as chemopreventers.
Nuclear factor kappa-B NF-kB is a signaling pathway that controls transcriptional activation of genes important for tight regulation of many cellular processes and is aberrantly expressed in many types of cancer.
Inhibitors of NF-kB pathway have shown potential anti-tumor activities. However, it is not fully elucidated in colon cancer. In this study, we demonstrate that quercetin induces apoptosis in human colon cancer CACO-2 and SW cells through inhibiting NF-kB pathway, as well as down-regulation of B-cell lymphoma 2 and up-regulation of Bax, thus providing basis for clinical application of quercetin in colon cancer cases. Apoptosis, colon cancer, nuclear factor-kappa B, quercetin How to cite this article: Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway.
Many epidemiological studies indicated that western style diet such as consumption of red meats is possibly associated with a high colon cancer incidence. Molecules intimately related to cancer cell survival, proliferation, invasion, and metastasis have been studied as candidates for molecular targeted agents.
NF-κB and cancer: how intimate is this relationship - Semantic Scholar
Inhibitory effect of quercetin on cell viability of human colon cancer cells. Once activated, NF-kB stimulates the transcription of genes encoding cytokines, growth factors, chemokines, and anti-apoptotic factors. Studies have suggested a series of pharmacologic inhibitors of NF-kB pathway to be potential anti-cancer agents,  such as IkB or IKK inhibitors,  ammonium pyrrolidinedithiocarbamate,  as well as selective ubiquitin proteosome inhibitors.
Our present study demonstrated that quercetin presented potent anticancer effects within an inhibitory effect on NF-kB, and could induce apoptosis of colon cancer cells in vitro, thus providing basis for clinical application of quercetin in colon cancer cases. Reagents and antibodies Quercetin, glyceraldehyde 3-phosphate dehydrogenase was purchased from Sigma Chemical Co St.
After incubation overnight, cells were treated as indicated concentration of quercetin and assessed by CCK-8 assay at 6 and 24 h respectively. Independent experiments were done in triplicate.