Niacin and protein relationship

The necessity of niacin in rats fed on a high protein diet.

niacin and protein relationship

Niacin, also known as nicotinic acid, is an organic compound and a form of vitamin B3, .. The liver can synthesize niacin from the essential amino acid tryptophan, requiring 60 mg of tryptophan to make 1 mg of niacin. Riboflavin, vitamin B6 and. protein, niacin-deficient ration (1) and the apparent dual r&e of niacin and tryptophane in siderable study on the mechanism of these relationships. It has been. Niacin deficiency is a condition that occurs when a person doesn't get enough or can't absorb niacin or its amino acid precursor, tryptophan.

Human studies have shown that 1 mg of nicotinamide is produced from 67 mg of tryptophan intake, and that the conversion ratio of tryptophan to nicotinamide is enhanced from mid to late pregnancy.

niacin and protein relationship

These findings have contributed to the determination of dietary reference intakes for niacin recommended in the Dietary Reference Intakes for Japanese Our findings suggest that the conversion of nicotinamide from tryptophan is important in maintaining niacin nutrition. The only route by which nicotinamide is biosynthesized is from tryptophan.

The necessity of niacin in rats fed on a high protein diet.

Niacin deficiency leads to pellagra, the typical symptoms of which are diarrhea, dermatitis, dementia, and death. Pellagra was common in the United States and parts of Europe in the early 20th century among people consuming foods containing low levels of niacin and tryptophan, such as corn.

niacin and protein relationship

Pellagra epidemics have been documented in several areas associated with a high dietary dependence on unfortified corn.

Thus niacin has been recognized as a vitamin.

Nutritional Aspect of Tryptophan Metabolism

Disorders resulting from abnormal tryptophan metabolism, such as Hartnup disease, show symptoms similar to those of pellagra. Conversion from tryptophan to nicotinamide requires nine steps, and this route is called the tryptophan—nicotinamide pathway Fig.

8 Vitamin Deficiencies That Show Up On Your Skin And Foods To Prevent Them

Medical conditions such as Hartnup's disease and carcinoid syndrome cause defects in tryptophan absorption, which will lead to a niacin deficiency. Classic niacin deficiency causes a condition called pellagra, the symptoms of which include dermatitis, dementia and diarrhea.

Does Vitamin B-6 Help Convert Tryptophan to Niacin in the Body? | Healthy Eating | SF Gate

If left untreated, the condition can lead to death. Sources The best sources of niacin are fish, such as tuna and halibut, and meat, such as beef, chicken, turkey and pork. These foods also contain tryptophan. Enriched and fortified cereals, bread, whole grains, seeds and legumes also contain niacin.

niacin and protein relationship

It is also found in eggs, dairy, tea, coffee and leafy green vegetables. Niacin supplements come in the form of nicotinic acid, which is used to treat high blood cholesterol. Recommendations The recommended dietary allowance, or RDA, of niacin for men is 16 milligrams a day, while women should get 14 milligrams.

niacin and protein relationship

Women who are pregnant should get 18 milligrams a day, and those who are breast-feeding should get 17 milligrams. Adequate dietary intake of protein generates good levels of tryptophan and therefore niacin.