La dispepsia es una afección que causa dolor en la parte superior del abdomen. Obtenga más información acerca de los signos y la. Nuestro objetivo fue evaluar los síntomas del síndrome de dispepsia funcional y su mejoría tras la erradicación del Helicobacter pylori. Se evaluaron Download Citation on ResearchGate | On Dec 31, , Martin H. Floch and others published Dispepsia (dispepsia funcional y dispepsia no ulcerosa) }.
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Provavelmente, a droga mais promissora e melhor estudada deste grupo de agentes redutores da sensibilidade visceral seja a fedotozina. New drugs for the treatment of functional dyspepsia. Arq Gastroenterol ;38 3: Current pharmacological treatment of functional dyspepsia is largely empirical and involves anti-secretory or prokinetic drugs.
Aims – To review recent advances in the understanding of the mechanisms involved in symptom vuncional in functional dyspepsia, as well as the development of new drugs that may interfere with these mechanisms, which may lead to more rational and effective treatment of this clinical condition.
Method – Systematic review of papers published funciona English for the last 10 years. Results – New drugs that increase propulsive gastroduodenal motor activity include new benzamides similar to cisapride, CCK-A blockers, agonists of opiate receptors and motilin agonists similar to erythromycin. A number of agents, including sumatriptan and buspirone, stimulates serotonin receptors in the myoenteric plexuses and have been shown to increase gastric accommodation to a meal.
New drugs for the treatment of functional dyspepsia
Finally, djspepsia number of new drugs that either increase thresholds for visceral perception or modify sensations is currently under investigation. This includes agents of several groups, such as octreotide, loxiglumide, ondansetron and other serotonin blockers, fedotozine and tricyclic antidepressant at low doses.
Conclusions – Although these new drugs may improve funcionxl pharmacological approach to the treatment of functional dyspepsia, there is a need for randomized, controlled trials to assess their efficacy. Moreover, difficulties related to the identification of the mechanisms underlying symptoms may limit the utilization of these new drugs. Intestinal diseases, drug therapy. Efficacy of fedotozine in functional dyspepsia: Annu Rev Med ; Clarithromycin accelerates gastric emptying by inducing powerful antral contractions [abstract].
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Psychotropic medications for the treatment of functional gastrointestinal disorders. Clin Perspect Gastroenterol ;2: Effect of the kappa agonist fedotozine on perception of gastric distension in healthy humans. Aliment Pharmacol Ther ; Influence of buspirone-induced fundus relaxation on the perception of gastric distension in man [abstract].
Dispepsia: Causas, Síntomas y Tratamiento
Diagnosing and treating patients with refractory functional gastrointestinal disorders. Ann Intern Med ; Feinle C, Read Ulceroza. Ondansetron reduces nausea induced by gastroduodenal stimulation without changing gastric motility. Am J Physiol ; Management of nonulcer dyspepsia. N Engl J Med ; Double-blind dose-response multicenter comparison of fedotozine and placebo in treatment of nonulcer dyspepsia.
Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans. Studies with the cholecystokinin-receptor antagonist loxiglumide. Cisapride or cimetidine in the treatment of functional dyspepsia. Hausken T, Berstad A. Wide gastric antrum in patients with non-ulcer dyspepsia: Effect of glyceryl trinitrate on antral motility and symptoms in patients with functional dyspepsia.
Dispepsia: Causas, Síntomas y Tratamiento –
Effects of trimebutine maleate on gastric motility in patients with gastric ulcer. Abnormal perception of visceral pain in response to gastric distension in chronic idiopathic dyspepsia.
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Efficacy and safety of the peripheral kappa agonist fedotozine versus placebo in the treatment of functional dyspepsia. Dyspepsia, antral motor dysfunction, and gastric stasis of solids.
Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients.
Role of cholecystokinin in the regulation of liquid gastric emptying and gastric motility on humans: Empiric therapy versus diagnostic tests in gastroesophageal reflux disease.
A medical decision analysis. Role of impaired gastric accommodation to a meal in functional dyspepsia. A placebo-controlled trial of buspirone, a fundus relaxing drug, in functional dyspepsia: Aliment Pharmacol Ther ;9: Gut ;45 Suppl II: Tanum L, Malt UF.
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