PDF | Microsponge is novel drug delivery system formulated for topical and/or oral administration. Microsponges are po-rous microspheres. The microsponges formulations were prepared by quasi-emulsion solvent . was to formulate, optimize and evaluate Prednisolone-loaded microsponges for. Formulation and evaluation of gel-loaded microsponges of diclofenac sodium for topical delivery. Hamid Hussain, Archana Dhyani, Divya Juyal.
|Published (Last):||7 February 2017|
|PDF File Size:||5.17 Mb|
|ePub File Size:||17.62 Mb|
|Price:||Free* [*Free Regsitration Required]|
Further on taking 0. Optimized gel formulation was subjected to stability testing as per ICH norms. The extrudability of prepared microsponge gel was found to be Polymer ratios led to superior drug loadings. The reason of this may be that the polymer employed was non-ionic and molecule can associate away from oil-water interface at higher concentrations.
Control of prolonged drug release and compression properties of ibuprofen microsponges with acrylic polymer, eudragit RS by changing their intraparticulate density. Characterization of microsponges Particle size analysis The mean particle size and polydispersity index PdI of all the batches of microsponges were measured using Mastersizer Malvern Instruments Ltd. Physical mixture showed similar thermal behavior as that of the pure drug but with lower intensity [ Figure 1b ].
Various multiparticulate approaches include formulation in the form of pellets; granules have been developed to achieve targeted and sustained release of drugs in the colon.
It can be inferred from the graph that the batch MS4 shows It was observed that no measurable drug release occurred up to 4 hours because of presence of time dependent polymer. A novel strategy for drug delivery system. Preparation and evaluation of microsponge loaded controlled release topical gel of acyclovir sodium.
J Chem Pharm Res ; 2 3: A 5 ml sample of the solution was withdrawn from the dissolution medium at regular interval by using a pipette fitted with a micro-filter and analysed drug release using a UV spectrophotometer model E Shimadzu, Japan at Int J Biopharm ; 3 2: Liposomal delivery enhances cutaneous availability of ciclopiroxolamine. The dispersed droplets of polymer solution of drug were solidified in the aqueous phase via diffusion of solvent By changing the concentration of PVA from 30 to 70 mg effect of external phase composition was assessed for formulations F7-F It was because of some drug dissolution in aqueous phase or solvent used.
Among the all prepared gels integrating FLZ-loaded microsponges, the F1 formulation was chosen for further study on the basis of its superiority in terms of physiochemical characterization, production yield, drug content, entrapment efficiency, morphology, surface topography, intact particles percent, and particle size. The rapid diffusion of ethanol good solvent for the polymer and drug into the aqueous medium might reduce the solubility of the polymer in the droplets, since the polymer was insoluble in the water.
The volume of dissolution medium was maintained constant by replacing with equivalent volume of SGF after each withdrawal. Physically cross-linked polyvinyl alcohol for the topical delivery of fluconazole. mcirosponges
In vitro skin permeation and in vivo microdialysis. Mandava SS, Thavva V: Over the last few years, extensive efforts have been focused on targeting a drug or drug delivery system in a particular region of the body for extended period of time, not only for local targeting of drugs but also for better control systemic drug delivery.
Formulation and evaluation of vanishing cream for scalp psoriasis. Drug release was found to be 2. Therefore, it is inferred from the study that microsponges2 have displayed enhanced dissolution of curcumin as compared to pure drug. The dissolution test was performed using ml of simulated gastric fluid pH 1. The topical formulation must exhibit acceptable mechanical characteristics such as low hardness and high adhesiveness. The release showed initial burst effect due to non-encapsulated prednisolone in formulation.
Microsponges based drug delivery system for augmented gastroparesis therapy: Improving drug solubility for oral delivery using solid dispersions.
Based on this fact, it is probable that such an effect may lead to an increase in effective drug levels within the colon with a consequent increase in absorption and blood levels, i. Optimization, formulation development and characterization of Eudragit RS loaded microsponges and subsequent colonic delivery. Precisely weighed quantity mg of microsponges containing drug was kept in ml PBS pH 7.
Therefore, prednisolone-loaded microsponges are proposed to formulate for oral controlled released of drug that minimize proximal absorption, allow high drug concentration in the colon and reduced side-effect.
Mechanical characterization of gels Structural analysis of carbopol gel and curcumin microsponges gel was done to determine their mechanical properties such as hardness, cohesiveness, and adhesiveness. During stability study formulation appearance was found pearl white, homogenous, smooth and no significant deviation in pH was seen. Formulation and development of anti-blemish preparations using microsponge technology.
Prednisolone loaded microsponges were prepared by quasi- emulsion solvent diffusion method. The shifting of endotherms and appearance of a new exotherm and decrease in heat of fusion indicate that some modifications have occurred. Support Center Support Center.
Formulation and evaluation of curcumin microsponges for oral and topical drug delivery
Evaluation of capsules The average weight of capsule formulations was found to be within pharmacopoeial limit.
Release profile of marketed fluconazole gel The drug release study for gel containing pure, unentrapped FLZ marketed formulation, F11 was carried out and release profile obtained was as depicted in Figure 5c.
After this drug release was carried out in phosphate buffer saline ecaluation 7. Basically, entrapment of the drug depends on the successful molecular association of the drug with the polymers. An average of five readings was used to calculate viscosity. Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles.